User Log On

Divinity Missionary Baptist Church Divinity Missionary Baptist Church

The Problem With the Treatment of Diabetic Foot Ulcers The Problem With the Treatment of Diabetic Foot Ulcers

   Discussion: The Problem With the Treatment of Diabetic Foot Ulcers
rosariawetzell · 23 days ago
In non-insulin-dependent, or type II, diabetes Phytage Labs Gluco Type 2 Review disturbed carbohydrate metabolism may be a result of a sluggish or insensitive secretory response in the pancreas or a defect in body tissues that requires unusual amounts of insulin, or the insulin secreted may be rapidly destroyed, inhibited, or in-activated in affected persons. A lack of insulin because of reduction in islet cell mass or destruction of the islets is the hallmark of the person with insulin-dependent, or type I diabetes. Pathophysiology Insulin is needed to support the metabolism of carbohydrates, fats and proteins, primarily by facilitating the entry of these substances into the cell. Insulin is needed for the entry of glucose into the muscle and fat cells, for the prevention of mobilization of fats from fat cells, and for storage of glucose as glycogen in the cells of liver and muscle. Insulin is not needed for the entry of glucose into nerve cells or vascular tissue. The chemical composition and molecular structure of insulin are such that it fits into receptor sites on the cell membrane. Here it initiates a sequence of poorly defined chemical reactions that alter the cell membrane to facilitate the entry of glucose into the cell and stimulate enzymatic systems outside the cell that metabolize the glucose for energy production. With deficiency of insulin, glucose is unable to enter the cell and its concentration in the bloodstream increases, the increased concentration in the bloodstream increases. The increased concentration of glucose (hyperglycemia) produces an osmotic gradient that causes the movement of body fluid from the intracellular space to the extracellular space and into the glomerular filtrate in order to "dilute" the hyperosmolar filtrate. When the glucose concentration in glomerular filtrate exceeds the threshold (180mg/dL), glucose "spills" into the urine along with an osmotic diversion of water (polyuria), a cardinal sign of diabetes. The Urinary fluid losses cause the excessive thirst (polydipsia) observed in diabetes. As might be expected, this water washout results in a depletion of other essential chemicals.

You must first create an account to post.